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- W2387603313 abstract "OBJECTIVE:To investigate the correlation between peripheral blood levels of matrix metalloproteinases-2(MMP-2),matrix metalloproteinases-9(MMP-9),tissue inhibitor of metalloproteinase-2(TIMP-2),tissue inhibitor of metalloproteinase-9(TIMP-1) and thyroid carcinoma.METHODS:The levels of MMP-2,MMP-9,TIMP-2,TIMP-1 in peripheral blood of 30 patients with thyroid carcinoma,27 patients with benign thyroid disease and 25 healthy volunteers were detected by ELISA and RT-PCR to analyse the correlation.RESULTS:The levels of MMP-2,MMP-9,TIMP-2,TIMP-1 in peripheral blood of patients with thyroid carcinoma were significantly higher than those of patients with benign thyroid disease and healthy volunteers.Expression of MMP-2 was(118.88±7.59),(51.13±6.89) and(47.55±8.61) ng/mL.Expression of TIMP-2 was(70.78±8.58),(36.05±7.34) and(32.56±7.27) ng/mL.Expression of MMP-9 was(110.18±15.49),(56.39±10.90) and(49.28±11.64) ng/mL.Expression of TIMP-1 was(63.62±9.95),(38.53±8.31) and(34.01±8.22)ng/mL(P0.05),while there were no significant difference between patients with benign thyroid disease and healthy volunteers(P0.05).CONCLUSION:The levels of MMP-2,MMP-9,TIMP-2 and TIMP-1 in peripheral blood are helpful to identify the thyroid carcinoma and it is an important pre-operation assessment method." @default.
- W2387603313 created "2016-06-24" @default.
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- W2387603313 date "2013-01-01" @default.
- W2387603313 modified "2023-09-23" @default.
- W2387603313 title "Correlations between peripheral blood levels of matrix metalloproteinases and its inhibiors and thyroid carcinoma" @default.
- W2387603313 hasPublicationYear "2013" @default.
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