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- W2387618532 abstract "Objective To establish a multi-center Wilms' Tumor cooperative group in China in association with the Chinese Pediatric Society. Methods The diagnosis and staging criteria, the surgery, chemotherapy and radiation were standardized in the WT-2003 Wilms tumor protocol. This protocol was first tested in Shanghai Children's Medical Center. After the approval of its efficacy and safety, the protocol was adopted by the cooperative group. The protocol was based on the National Wilms’ Tumor Study (NWTS) criteria of U.S.A, aiming to reduce treatment of low-stage, favorable-histology (FH) tumors without impairing survival and to improve prognosis of stage III and IV (FH) and unfavorable-histology (UFH) tumors with more intensive chemotherapy. Chemotherapy duration ranges from 18 weeks to 24 weeks with different intensity depends on individual criteria. For those un-resectable tumors, two courses of Ifosfamide, Vcr and VP-16 are recommended as pre-surgery therapy. No radiation therapy is recommended for all stage I and FH stage II. No randomized comparison was attempted. Results Patients were recruited from 7 hospitals. Four patients were excluded from the final analysis because they did not meet the selection criteria.A total 52 patients, with age between 7 months to 12 years old (median 29 months) were enrolled. Pathology revealed 35 FH,eight UFH,five clear cell,one rhabdoid and two un-differentiated.There were seventeen patients with stage I,eleven with stage II,seventeen with stage III, six with stage IV and one stage V tumors. Forty-eight (93%) patients achieved complete remission (CR). One relapsed after CR 24 months and reached second CR after intensive chemotherapy and ABMT.No therapy-related death occurred.Disease free survival (DFS) is seen in 86% of patients and its duration ranged from 3 to 72 months (average=13 months).All but five have stopped the treatment according to the protocol.Conclusions Multi-center cooperative group model for childhood cancer is feasible in China. The medical care for childhood can-cer can be improved through this model." @default.
- W2387618532 created "2016-06-24" @default.
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- W2387618532 date "2006-01-01" @default.
- W2387618532 modified "2023-09-25" @default.
- W2387618532 title "Preliminary results of WT-2003 Wilms’ tumor protocol by the chinese pediatric oncology society" @default.
- W2387618532 hasPublicationYear "2006" @default.
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