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- W2387629473 abstract "Objective To explore the expression of IGF-1 receptor by orbital fibroblasts(OFs) from patients with thyroid associated ophthalmopathy(TAO) and its effect in the pathogenesis of TAO.Methods Human OFs were harvested and cultured from the connective tissue of patients who were finally diagnosed as TAO undergoing orbital decompression surgery and some ordinary patients without any inflammatory disease undergoing eye enucleate surgery because of trauma.The expression of IGF-1R of OFs was detected by confocal microscopy and flow cytometry,then comparing and analyzing the expression of IGF-1R between patients with TAO and controls by statistical method.Results The expression of IGF-1R by OFs from patients with TAO[(72.6±10.4)%] was significantly different comparing with controls [(27.8±10.7)%](P0.05).After observation and quantitative analysing by confocal microscopy,we found IFG-1R was over expressed by OFs of TAO patients than normal controls and this receptor was mainly located in the ambient of nucleus and cytoplasm.Conclusions IGF-1R is over expressed by OFs from patients with TAO compared with control donors in vitro." @default.
- W2387629473 created "2016-06-24" @default.
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- W2387629473 date "2011-01-01" @default.
- W2387629473 modified "2023-09-27" @default.
- W2387629473 title "The over expression of IGF-1 receptor by orbital fibroblasts in thyroid associated ophthalmopathy patients" @default.
- W2387629473 hasPublicationYear "2011" @default.
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