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- W2387636986 abstract "Objective To study the effect of interleukin-10 (IL-10) on the proliferation and collagen synthesis induced by arginine vasopressin(AVP) in cultured cardiac fibroblasts(CFs). Methods The CFs of neonatal Sprague-Dawley rats were isolated and cultured. Cell number were determined by MTT assay (A_ 490 value). Cell cycle distribution was assessed using flowcytometry technique. Ⅰ-type and Ⅲ-type collagen mRNA in CFs were analyzed by the reverse transcriptase-polymerase chain reaction (RT-PCR). Results (1)10~ -7 mol/L AVP significantly increased A_ 490 value of CFs(0.216±0.013 vs control: 0.132±0.006, P0.01). (2) IL-10 attenuated the A_ 490 value in a concentration dependent manner. (3)The percentage of the cells in S stage(12.30±0.71 vs 4.22±0.48, P 0.01) and proliferation index(PI 19.58±0.88 vs 7.12±0.62, P 0.01) were markedly increased in AVP goup compared with the control. (4)The mRNA abundances of Ⅰ type(1.45±0.06 vs 1.03±0.05, P0.01)and Ⅲ type collagen stimulated by AVP(1.06±0.06 vs 0.84±0.05, P0.01) were significantly higher than that of the control. IL-10 attenuated the mRNA abundances of Ⅰ and Ⅲ-type collagen of AVP group in a concentration dependent manner. ConclusionIL-10 effectively inhibits the cell proliferation and collagen synthesis of CFs induced by AVP, suggesting IL-10 may play a role in the regression of heart remolding." @default.
- W2387636986 created "2016-06-24" @default.
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- W2387636986 date "2006-01-01" @default.
- W2387636986 modified "2023-09-27" @default.
- W2387636986 title "Effects of Interleukin-10 on the Proliferation and Collagen Synthesis Induced by Arginine Vasopressin" @default.
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