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- W2387637538 abstract "Objective:To observe the expression of local angiotensin-converting enzyme 2 (ACE-2) in rat liver and its relationship with preservation injury (PI) after transplantation,so as to determine the possible role of local renin-angiotensin system (RAS) in PI caused by the cold-preservation in liver transplantation.Methods:The donor liver grafts were divided into cold preservation (CP) and non-cold preservation (NCP) groups;we also included a sham operation group without transplantation.The mRNA and protein levels of ACE-2 in the transplanted livers were detected by quantitative real-time PCR and Western blotting assay,respectively.The location of ACE-2 protein and pimonidazole in liver was detected by immunohistochemistry.Furthermore,histological evaluation was applied to verify the extent of liver damage.Results:Histological injuries of different degrees existed after liver transplantation; the injury was more obvious in the CP group.Compared with the sham operation group,the mRNA and protein expression of ACE-2 was significantly increased after liver transplantation (P0.05 or P0.01),and the expression of the CP group was significantly higher than that of the NCP group (P0.05).Pimonidazole staining was positive around the hepatic veins in the transplantation groups,and the intensity of staining was positively correlated with the expression of ACE-2 mRNA (r=0.78,P0.001).Conclusion:It is indicated that ACE-2 expression is closely associated with tissue hypoxia during cold preservation-induced PI ,and local RAS may play an important role in PI during liver transplantation." @default.
- W2387637538 created "2016-06-24" @default.
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- W2387637538 date "2009-01-01" @default.
- W2387637538 modified "2023-09-22" @default.
- W2387637538 title "Expression of angiotensin-converting enzyme 2 is increased during preservation injury of liver transplantation in rats" @default.
- W2387637538 hasPublicationYear "2009" @default.
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