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- W2387641010 abstract "Objective To investigate the expressions of microRNA-451(microRNA-451)and protein kinase B(PKB)in rat model of lung ischemia reperfusion and the relationship between the two parameters. Methods Wistar rats were divided into five groups in random as control group,1-hour-ischemia group,1-hour-reperfusion,3-hour-reperfusion and 6-hour-reperfusion groups,with 10 rats in each group.With real-time fluorescent quantitative PCR(RT-qPCR),the expressions of microRNA-451 and PKB in each group were detected. Results Compared with the control group,the expression of microRNA-451 in the ischemia group,1-hour-reperfusion,3-hour-reperfusion and 6-hour-reperfusion groups showed a tendency of up-regulation first and then down-regulation,of which,the expression of microRNA-451 in the 3-hour-reperfusion group being the highest,the differences were significant(F=17 244.32,P0.05).A comparison of PKB expression between each group showed that it was higher in the control group and in 6-hour-reperfusion group,and the lowest seen in 3-hour-reperfusion(F=136.02,P0.05). Conclusion In the process of lung ischemia reperfusion in rats,microRNA-451 promotes cell apoptosis possibly through regulating PKB pathway." @default.
- W2387641010 created "2016-06-24" @default.
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- W2387641010 date "2014-01-01" @default.
- W2387641010 modified "2023-09-23" @default.
- W2387641010 title "THE EXPRESSIONS OF MICRORNA-451 AND PROTEIN KINASE B IN LUNG ISCHEMIA-REPERFUSION MODEL OF RAT" @default.
- W2387641010 hasPublicationYear "2014" @default.
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