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- W2387643559 abstract "Objective To explore the role of SEB in relations between chronic rhinosinusitis(CRS)and asthma,and to determine the contribution of the CRS-derived SEB to the pathogenesis of asthma.Methods A total of 38 patients with both CRS and asthma underwent functional endoscopic sinus surgical treatment.Serum specific IgE and cytokines,clinical symptoms of CRS and asthma were detected after the operation.The peripheral blood mononuclear cells(PBMCs)were separated and cultured.The Th2 response in the cultured PBMCs in the presence or absence of specific antigen and SEB was observed.Twenty-five patients with CRS alone,23 patients with asthma alone and 20 healthy controls without history of asthma or CRS were chosen as the control groups.Results The patients with both CRS and asthma obtained satisfactory results in the improvement of clinical symptoms and lung function tests after sinus surgery.Clinical symptom of the patients with CRS alone were improved after sinus surgery.Compared with the preoperative data,Th2 cytokines,IL-4 and IL-5 decreased significantly after operation.The indexes had no significant changes before and after operation in the control groups.The Th2 response was generated in the cultured PBMCs stimulated by specific antigen,but not in the control groups.Conclusion The results indicate that bacterial superantigen SEB plays a crucial role in sustaining the Th2 response of the low airway hypersensitivity related to sinusitis." @default.
- W2387643559 created "2016-06-24" @default.
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- W2387643559 date "2007-01-01" @default.
- W2387643559 modified "2023-09-26" @default.
- W2387643559 title "Staphylococcal enterotoxin B plays a role in sustaining Th2 cell polarization in the low airway hypersensitiveity" @default.
- W2387643559 hasPublicationYear "2007" @default.
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