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- W2387645429 abstract "Objective To investigate the effect of simvastatin on the acute phase serum amyloid protein A(A-SAA) in patients with coronary disease and type 2 diabetes mellitus.Methods The subjects included 16 patients with type 2 diabetes mellitus but with no coronary disease(group A) and 34 patients complicated with both type 2 diabetes mellitus and coronary disease,who were further divided into non-simvastatin treatment group(group B,n=16) and simvastatin treatment group(group C,n=18).All the patients underwent treatment for 12 weeks and their levels of plasma lipids and A-SAA were measured before and after the treatment.Results At the end of the treatment,the A-SAA levels in groups B and C were higher than those in group A;the levels of total chloesterol(TC),triglyceride(TG) and A-SAA decreased and the levels of high density lipoprotein cholesterol(HDL-c) significantly increased(P0.01).Conclusion In addition to its effects of decreasing TC and increasing HDL,simvastatin can exert its anti-atherosclerotic effect by reducing the expression of A-SAA." @default.
- W2387645429 created "2016-06-24" @default.
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- W2387645429 date "2010-01-01" @default.
- W2387645429 modified "2023-09-23" @default.
- W2387645429 title "The effect of simvastatin on A-SAA in patients with T2DM and coronary disease" @default.
- W2387645429 hasPublicationYear "2010" @default.
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