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- W2387647611 abstract "In this study, we aim to establish an in vitro expansion method for CD4+CD25+regulatory T cells(Treg) and detect its function. CD4+CD25+Treg was separated and purified from peripheral blood mononuclear cell by flow cytometry with 98% purity and 95% of purified cells were Foxp3 positive. The purified CD4+CD25+Treg was further stimulated in vitro with IL-2 and anti-CD3/CD28 monoclonal antibody for 1 to 6 weeks. Cell proliferation of stimulated Treg was detected by radioactive H3incorporation assay and a thousandfold increase was found after 6-week culture. Furthermore, the expression of Foxp3 and the secretion of IL-10/TGF-β were found significantly lower in stimulated Tregs than those in non-stimulated. In conclusion, this study successfully established an expansion method for CD4+CD25+Tregs, and Treg lose their Foxp3 marker after in vitro expansion." @default.
- W2387647611 created "2016-06-24" @default.
- W2387647611 creator A5075378610 @default.
- W2387647611 date "2014-01-01" @default.
- W2387647611 modified "2023-09-23" @default.
- W2387647611 title "In vitro cell expansion and function detection of human peripheral blood mononuclear cell derived CD4~+CD25~+ regulatory T cells" @default.
- W2387647611 hasPublicationYear "2014" @default.
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