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- W2387655307 abstract "OBJECTIVE:To approach the influence of human erythropoietin on the expression of Th17 cell factor in serum of mice with ulcerative colitis.METHODS:Thirty BALB/C mice were randomly divided into normal group,DSS model group and hEPO group,10 mice in each group.UC murine was induced by dextran sodium sulfate.All mice disease activity index score(DAI score) were calculated.Mice were killed at eighth day,the colon tissues were conducted pathological section and score,serum content of IL-6 and IL-17A were assayed by Elisa kits.RESULTS:The score of DAI and histological damage score,serum IL-6 and IL-17A content were higher in model group than that in normal group(P0.05),which were significantly improved by erythropoietin treatment,the difference had statistical significant(P0.05).CONCLUSION:Human erythropoietin can effectively lessen the clinical symptom and injury of intestinal tract of mouse with UC,we supposed that hEPO inhibits the expression and release of serum IL-6,and reduces Th17 cell differentiation into IL-17A,and finally reaches to the purpose of treatment of UC." @default.
- W2387655307 created "2016-06-24" @default.
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- W2387655307 date "2012-01-01" @default.
- W2387655307 modified "2023-09-23" @default.
- W2387655307 title "The Effect of Human Erythropoietin on Expression of Th17 Cell Fator in Serum of Murine with Ulcerative Colitis" @default.
- W2387655307 hasPublicationYear "2012" @default.
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