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- W2387661446 abstract "Objective: To explore the character of high cardiovascular risks in hypertensive patients of dampness-phlegm constitution( DPC) based on constitution classification of traditional Chinese medicine,and seek the genetic markers of these high risks. Methods: A total of 506 hypertensive patients were involved,among which 261 cases were DPC and 245 cases were non-DPC. The left ventricular mass index( LVMI) and carotid intima-media thickness( IMT) were measured,and the correlation between LVMI and carotid IMT and 4 single nucleotide polymorphisms( SNP) in adiponectin gene was analyzed.Results: The LVMI was( 160. 13 ± 5. 29) g /m2 in DPC group and was( 143. 24 ± 5. 46) g /m2 in non-DPC group,with a statistical difference between the two groups( P = 0. 029); the carotid IMT was( 0. 66 ± 0. 01) mm in DPC group and(0.63 ±0.01) mm in non-DPC group,with a statistical difference between the two groups( P =0.021). In the DPC group,the LVMIs of patients with rs182052 A,rs182052 G and rs182052 AG genotypes were( 141. 87 ± 14. 21) g /m2,( 188. 17 ±10. 65) g /m2and( 176. 22 ± 10. 35) g /m2 respectively,and the LVMI was the highest in patients with rs182052 G genotype( P =0.035). Conclusion: The conditions of LVMI and carotid IMT in hypertensive patients with DPC was worse than patients with non-DPC and the rs182052 G in adiponectin gene may be one of the genetic markers of high cardiovascular risk in hypertensive patients with DPC." @default.
- W2387661446 created "2016-06-24" @default.
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- W2387661446 date "2014-01-01" @default.
- W2387661446 modified "2023-09-23" @default.
- W2387661446 title "Correlation of High Cardiovascular Risk with Adiponectin Gene Polymorphisms in Hypertensive Patients with Dampness-phlegm Constitution" @default.
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