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- W2387661666 abstract "Objective To investigate the effects of cyclinL2 of apoptosis on human gastric adenocarcinoma cancer cell line treated by cisplatin(DDP),5-fluorouracil(5-Fu) and docetaxel(DOC).Methods The human gastric adenocarcinoma cell line BCG-823 was chosen for this experiment.The inhibitory effects of chemotherapeutical drugs on BCG-823 cell line were assayed with MTT test.Plasmid pCCNL2-wt containing the full-length coding region of human cyclinL2 and antisense plasmid pCCNL2-AS was used for transfection.The parental cell and negative control cell with empty vector were used as controls.Apoptosis was determined by flow cytometry.Results All three drugs obviously inhibited the gastric adenocarcinomacell growth with dose dependent.Apoptosis and inhibitory rate in cyclinL2 gene overexpression cells were higher than that of the control groups.Conclusion CyclinL2 gene may play a critical role in the lung cancer cell apoptosis induced by chemotherapeutical drugs." @default.
- W2387661666 created "2016-06-24" @default.
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- W2387661666 date "2007-01-01" @default.
- W2387661666 modified "2023-09-22" @default.
- W2387661666 title "The Role of CyclinL2 on the Apoptosis of Gastric Adenocarcinoma Cell Line Induced by Chemotherapeutical Drugs" @default.
- W2387661666 hasPublicationYear "2007" @default.
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