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- W2387661848 abstract "Objective Using Tet regulation system,the feasibility of gene therapy for human breast carcinoma xenografts in nude mice induced by antibiotics in vivo were investigated in this study.Methods Mouse breast cancer model was established by transferring human breast cancer cells subcutaneously into the BALB/C nude mice to make xenografts.Recombinant retroviruses containing HSVtk and Tet-On gene were constructed respectively for treatment.The growth of tumor was tested and pathological analysis was performed after ganciclovir(GCV) and retroviruses treatment induced by doxycycline(Dox).The antitumor effect was observed to evaluate the regulatory therapy in breast cancer model of nude mice.Results After GCV and retroviruses treatment,under induction of Dox,volume of tumors of nude mice model was decreased remarkably,tumor growth was retarded and survival period was prolonged compared with the control groups(P(0.05)).Some of infiltrating inflammatory cells and strong eosinophil cells could be observed in the tumor mass stained with hematoxylin and eosin.Conclusion Recombinant retroviruses containing Tet regulation system and suicide gene can successfully used in cancer gene therapy and killed tumor cells in breast cancer model of nude mice after GCV treatment induced by antibiotics(Dox) in vivo." @default.
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- W2387661848 date "2006-07-05" @default.
- W2387661848 modified "2023-09-27" @default.
- W2387661848 title "Gene Therapy for Human Breast Carcinoma Xenografts in Nude Mice Induced by Antibiotics in Vivo" @default.
- W2387661848 doi "https://doi.org/10.3971/j.issn.1000-8578.2296" @default.
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