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- W2387662657 abstract "Objective To investigate the molecular mechanism of nm23-H1 gene on the targeted regulation effect for PKA signal pathway of lung cancer cell.Methods The PKA activity,CREB and p-CREB expression levels among primary human high-metastatic large cell lung cancer cell line(L9981),vector transfection lung cancer cell line(L9981-pLXSN) and nm23-H1 gene transfection lung cancer cell line(L9981-nm23-H1) by radioimmunoassay and Western blot methods respectively.Results(1)The activity of PKA in L9981-nm23-H1 lung cancer cell line [1.906±0.034μmol/(min·g)]was significantly higher than that in L9981[0.441±0.021μmol/(min·g)] and L9981-pLXSN lung cancer cell lines[0.443±0.059μmol/(min·g)](P=0.000),but no significant difference of the PKA activity was observed between L9981 and L9981-pLXSN lung cancer cell lines(P0.05);(2)No significant difference of the expression level of CREB was observed among L9981,L9981-pLXSN and L9981-nm23-H1 lung cancer cell lines(P0.05),but the expression level of p-CREB in L9981-nm23-H1 lung cancer cell line was remarkably higher that that in L9981 and L9981-pLXSN lung cancer cell lines(P=0.000).Conclusion(1)Transfection of nm23-H1 gene can significantly up-regulate the activity and expression related invasion and metastasis of human high-metastatic large cell lung cancer might be related to its effecfs of activating PKA signal pathway." @default.
- W2387662657 created "2016-06-24" @default.
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- W2387662657 date "2006-01-01" @default.
- W2387662657 modified "2023-09-26" @default.
- W2387662657 title "An experimental study on the targeted regulation effect of the nm23-H1 gene for PKA signal pathway of lung cancer cell" @default.
- W2387662657 hasPublicationYear "2006" @default.
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