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- W2387663684 abstract "Objective To analyze the relationship between gastroduodenal diseases susceptibility and IL-1B-31 and TNF-α-1031 gene polymorphism between people,provide a new treatment concept for diagnosis and prevention of gastroduodenal diseases. Methods 52 cases of chronic gastritis,48 cases of duodenal ulcer,50 cases of gastric cancer patients and 100 cases of healthy population were detected on IL-1B-31 and TNF-α-1031 gene polymorphism by allele-specific PCR and PCR-restriction fragment length polymorphism method. Results The results showed that there were C / T polymorphisms in IL-1B-31 and TNF-α-1031 sites,included C / C,T / T,C / T three genotypes,282 bp band was found in IL-1B-31 gene PCR amplification product and cleavaged by restriction endonuclease Alu I,the C / C type turned to 282 bp,T / T type turned to 100 bp and 182 bp,C / T type turned to 100 bp,182 bp and 282 bp,452 bp was found in TNF-α-1031 gene PCR amplification product T / C type,which were T primer and C primer,452 bp was found in C / C type coupled with C-type primer,while band was not found in T-type primer,452 bp band was found in T / T type coupled with T-type primer,while band was not found in C-type; In this experiment,all genotypes and allele frequencies conformed to Hardy-Weinberg genetic equilibrium. By χ2test and analysis,there was no significant difference of IL-1B-31 gene genotype frequencies distribution in observation group compared with control group. Compared with the control group,TNF-α-1031 genotype frequencies in gastritis patients with H. pylori,duodenal ulcer patients with H. pylori fection and gastric cancer patients with H. pylori were significant differences(P 0. 05); In the four groups of risk comparison,the risk of patients with TNF-α-1031 C / C occurred chronic gastritis OR = 5. 69(95% CI: 1. 00 ~ 33. 84),the risk of the occurrence of duodenal ulcer OR = 6. 87(95% CI: 1. 19 ~ 40. 63),the risk of gastric cancer OR = 5. 98(95% CI: 1. 09 ~ 35. 36). By Spearman rank correlation analysis,correlation coefficients of IL-1B-31 and chronic gastritis,duodenal ulcers and gastric cancer were r1= 0. 879,r2= 0. 826,r3= 0. 901; the correlation coefficients of TNF-α-1031 and chronic gastritis,duodenal ulcer and gastric cancer were r1= 0. 426,r2= 0. 328,r3= 0. 645. Conclusion There is no correlation between the IL-1B-31 genotype and Helicobacter pylori-related gastroduodenal diseases,Gastritis,duodenal ulcer susceptibility and TNF-α-1031 genotype exist relationship." @default.
- W2387663684 created "2016-06-24" @default.
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- W2387663684 date "2014-01-01" @default.
- W2387663684 modified "2023-09-25" @default.
- W2387663684 title "Study on the relationship between gastroduodenal disease susceptibility and IL-1B-31 and TNF-α-1031 gene polymorphism" @default.
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