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- W2387665639 abstract "Objective: To investigate the enhancing effect of octreotide on the anti-proliferative effect of paclitaxel against non-small cell lung cancer ceils and to explore the possible mechanisms.Methods:The expression of somatostatin receptor(SSTR)1-5 mRNA was examined in non-small cell lung cancer cell lines A549 and H157 by RT-PCR.The inhi- bitory effect of octreotide(different treatment periods and concentrations)on the growth of A549 and H157 cells was evaluated by MTT assay and the morphological change of the cells was observed by microscopy after octreotide treatment. MTT assay was also used to investigate whether combinations of octreotide and paclitaxel had synergetic interaction.Apop- tosis of A549 cells was analyzed bv flow cytometry after treatment with paclitaxel,octroetide,or a combination of both.The changes of MDR-1,MRP-1,BCRP expression in the cells was evaluated by real-time PCR after treatment with octreotide. Results: The expression of SSTR1-5 mRNA was detected in A549 cells and only SSTR1 and SSTR4 mRNA was detected in H157 cells.Octreotide inhibited growth of A549 cells in a time(24h,48h,72h)and dose(1-1 000 nmol/L)- dependent manner;morphological changes of the injured cells were observed under microscope;Octreotide had no effect on H157 ceils.The anti-proliferative effect of paclitaxel on A549 cells was enhanced by octreotide(125 nmol/L,250 nmol/L,500 nmol/L,P0.01);octreotide showed no enhancing effect on the chemo-sensitivity of H157 cells. Octreotide induced cell apoptosis in A549 cells,but the apoptosis of A549 cells induced by paclitaxel was not promoted by octreotide.Octreotide down-regulated MDR-1,MRP-1 expression in A549 cells(P0.05,P0.01),but not in H157 cells.Conclusion:Octreotide can promote the anti-proliferative effect of paclitaxel on SSTR-positive non-small cell lung cancer cells;and down-regulation of muhidrug related genes may be one of the possible mechanisms." @default.
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- W2387665639 date "2008-01-01" @default.
- W2387665639 modified "2023-09-23" @default.
- W2387665639 title "Octreotide enchances the anti-proliferative effect of paclitaxel against non-small cell lung cancer cells" @default.
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