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- W2387667710 abstract "Objective:To investigate the relationhsip between hepatitis B virus genotypes and YMDD mutant.Methods:Serum samples from 238 patients with chronic HBV infection who were treated with Lamivudine(100mg/d)for average 12(9-24) months were collected and tested for HBV genotypes by the multiplex type-specific primers, direct sequence and gene chips to detect YMDD and pre-C/BCP mutants. Results: Of the 238 patients, 190(79.8%) were genotype B, 41(17.2%) were genotype C and 7(3.0%) were mixed genotype B and C. Of the 238 patients, 44 appeared YMDD mutant, the rate of YMDD mutant was 18.5%. No significant difference of YMDD mutant was found between patients with genotype B and C (17.4% vs 19.5%,P0.05). Among 44 patients with YMDD mutant, there were 30 patients with L528M mutant, 7 with pre-C(nt1896)mutant and 13 with double-mutant(nt1762/1764) in BCP domain. Conclusion:Genotype B and C were the dominant genotypes of HBV in this area. The emergence of YMDD mutant was not different between genotype B and C. The patients with YMDD mutant associated with L528M, pre C and BCP domains mutants." @default.
- W2387667710 created "2016-06-24" @default.
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- W2387667710 date "2005-01-01" @default.
- W2387667710 modified "2023-09-26" @default.
- W2387667710 title "Correlation of Hepatitis B Virus Genotypes and YMDD Mutant" @default.
- W2387667710 hasPublicationYear "2005" @default.
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