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- W2387668955 abstract "Objective To study the changes of Caspase-8 and Caspase-3 proteins in K562 cells during apoptosis induced by psoralen(PSO) plus ultraviolet A(UVA)(PUVA).Methods The K562 cells were treated with PSO extracted from Chinese medicine psoralea fruits in different concentrations plus UVA(360 nm) in different irradiation time or not.Apoptosis ratios,ultrastructure changes and expression of Caspase-8 and Caspase-3 proteins were detected.The factorial design and analysis of variance were used to analyze the interaction among the factors.Results PSO,UVA and PUVA all increased the apoptosis ratios and UVA and PUVA up-regulated the expression of Caspase-8 and Caspase-3 proteins,but the effects of PUVA were the strongest.There were obvious ultrastructure changes in apoptosis after treatment with PUVA.Conclusion PUVA can induce the apoptosis of K562 cells through activating Caspase-8 and Caspase-3 genes." @default.
- W2387668955 created "2016-06-24" @default.
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- W2387668955 date "2008-01-01" @default.
- W2387668955 modified "2023-09-28" @default.
- W2387668955 title "Changes of Caspase-8 and Caspase-3 Proteins in K562 Cells during Apoptosis Induced by PUVA" @default.
- W2387668955 hasPublicationYear "2008" @default.
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