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- W2387677923 abstract "Objective:To study the effects of membrane-bound IL-15 in combination with retinoic acid early transcript 1e(RAE1e) on cytotoxicity of NK cells.Methods:Three derivatives of mouse pro-B lymphocyte cell line BaF3,expressing membrane-bound IL-15(termed BaF3/mbl5),or RAEle(termed BaF3/RAE),or both membrane-bound IL-15 and RAE1e(termed BaF3/mbl5/RAE) were respectively constructed in the previous study.Mouse NK cells were isolated and stimulated with irradiated BaF3 derivatives.Phenotype analysis of NK cells was performed by flow cytometry. Meanwhile,perforin and granzyme B expressions were detected in NK cells by intracellular staining;the cytotoxicity of NK cells against YAC1 lymphoma target cells was evaluated by flow cytometry.Results:NK cells stimulated with BaF3-mbl5-RAE cells expressed higher levels of CD25,CD44,FasL and CD107a compared to NK cells stimulated with BaF3/mbl5 or BaF3/RAE cells.However,BaF3-mbl5-RAE cells showed no effects on perforin and granzyme B production of NK cells.When the effector to target ratio was 20:1,the cytotoxicity rates of BaF3/mbl5-stimulated NK cells,BaF3/RAE- stimulated NK cells and BaF3/mbl5/RAE-stimulated NK cells against YACl cells were(39.7±2.9)%,(45.3±2.3)%and(59.0±6.9 )%,respectively,and significantly increased compared with that of BaF3-stimulated NK cells ([28.3±1.5]%,P 0.01 ).Furthermore,BaF3/mbl5/RAE-stimulated NK cells exhibited higher cytotoxicity on YACl cells than BaF3/mbl5-stimulated or BaF3/RAE-stimulated NK cells(P0.05).Conclusion:IL-15 combined with RAElepromotes the activation and cytotoxicity of NK cells." @default.
- W2387677923 created "2016-06-24" @default.
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- W2387677923 date "2011-01-01" @default.
- W2387677923 modified "2023-09-25" @default.
- W2387677923 title "Membrane-bound IL-15 combined with RAE-1ε enhances cytotoxicity of mouse NK cells" @default.
- W2387677923 hasPublicationYear "2011" @default.
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