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- W2387679537 abstract "Objective To investigate the application of hyaluronic acid (HA), collagen type Ⅳ (ColⅣ), N terminal procollagen Ⅲ (PⅢNP) and laminin (LN) in the diagnosis of chronic fibrotic disease. Methods HA, PⅢNP and LN were determined with RIA and ColⅣ with ELISA. Relationship between serum markers and histological grades of inflammation and fibrosis was evaluated. Results Serum HA and ColⅣ elevated significantly with the progress of inflammation and fibrosis ( P 0.01, P 0.05), indicating that there existed excellent correlation between HA or ColⅣ and histological grades. PⅢNP increased with the progress of inflammatory severity but no significant change was found in different fibrotic grades. Serum LN remained unchanged in different histological grades. Conclusion HA and ColⅣ are of practical diagnostic value with the 4 serum markers investigated. The level of HA reflects not only the existence but also the progress of fibrotic or inflammatory change in chronic hepatic disease. The application of PⅢNP and LN for diagnostic use are not confirmed, indicating that further study is required for elucidation." @default.
- W2387679537 created "2016-06-24" @default.
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- W2387679537 date "2001-01-01" @default.
- W2387679537 modified "2023-09-26" @default.
- W2387679537 title "Application of serum markers in the diagnosis of fibrotic liver disease" @default.
- W2387679537 hasPublicationYear "2001" @default.
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