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- W2387679691 abstract "OBJECTIVE:To investigate the relationship between the polymorphism of XRCC1 and susceptibility to gastric cancer in Shandong Province.METHODS:A 1∶1 case-control study of 107 patients with primary gastric cancer and none cancer or alimentary inpatients as a control group(matched for ages ±5 years and sex)in Shandong Province was conducted to analyze XRCC1 polymorphism at Arg194Trp,Arg280His,Arg399Gln.Gene types by PCR-based restriction fragment length polymorphism techniques.RESULTS:The frequencies of 194Trp allele gene in the cases and controls were 53.27% and 43.93%,those of 280His were 12.15%,15.89% and 399Gln were 54.21%,46.73% respectively,and no difference was found in both groups.However in the group of older than 60 years with 194Trp allele gene had an OR of 2.303(95%CI=1.061-4.996,P=0.033)and the risk for occurrence of gastric cancer was higher.The 194Trp allele gene added the risk to the occurrence of gastric cardia carcinoma(OR=2.766,95%CI=1.106-7.825,P=0.049)and remote metastasis(OR=2.188,95%CI=1.022-4.688,P=0.042).CONCLUSIONS:The XRCC1 Arg194Trp polymorphism can add the risk to the occurrence of gastric cancer in old people,which can elevate the occurrence of gastric cardia carcinoma and promote remote metastasis of gastric carcinoma too.No significant correlation is found between XRCC1 gene polymorphism of Arg280His and Arg399Gln and gastric carcinoma." @default.
- W2387679691 created "2016-06-24" @default.
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- W2387679691 date "2009-01-01" @default.
- W2387679691 modified "2023-09-28" @default.
- W2387679691 title "Correlation of polymorphism of DNA repair gene-XRCC1 with susceptibility to gastric cancer in Shandong Province" @default.
- W2387679691 hasPublicationYear "2009" @default.
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