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- W2387682393 abstract "Objective: To clarify the relationship between the two malignancy diseases: small lymphocytic lymphoma/chronic lymphocytic leukemia(SLL/CLL) and chronic myelogenous leukemia(CML) in the same patient.Methods: We performed bone marrow smear,lymph node biopsy,the cytogenetic and genome research,fluorescence in situ hybridization(FISH),and flow cytometry(FCM) in a 52-year-old male patient who developed Ph-positive CML 5 years after the onset of SLL/CLL and reviewed the related literature.Results: Bone marrow smear and the lymph node biopsy confirmed the SLL/CLL diagnosis and FISH detection showed no Philadelphia(Ph)-positive chromosome in the early stage of disease.After 5-year chemotherapy,bone marrow culture demonstrated an abnormal karyotypes of 46,XY,t(9;22)(q34;q11).The bone marrow of the patient displayed typical features of CML.FCM detection confirmed that two abnormal clones coexisted in the same patient.Conclusion: These results indicate that the two neoplastic populations originated independently,the second neoplasia may be related with the over-therapy of the first neoplasia." @default.
- W2387682393 created "2016-06-24" @default.
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- W2387682393 date "2008-01-01" @default.
- W2387682393 modified "2023-09-25" @default.
- W2387682393 title "Chronic myeloid leukemia developed in the course of small lymphocytic lymphoma therapy and related literature review" @default.
- W2387682393 hasPublicationYear "2008" @default.
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