Matches in SemOpenAlex for { <https://semopenalex.org/work/W2387683818> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2387683818 abstract "Objective To investigate in vivo the effects of combined neurotrophins injection(BDNF and CNTF) on survival of retinal ganglion cells(RGCs) after optic nerve injury.Methods Sixty healthy female Sprague-Dawly(SD) rats weighing 200～225 grams were randomly divided into one of the 4 groups:control group,BDNF group,CNTF group and combined neurotrophins(BDNF and CNTF) group.Each group of rats was further stratified in fives into three time levels from injury:7 day,14 day and 21 day,tested on the right eye in contrast to the left one which was kept intact.The RGCs of all rats were labeled with fluorogold.Seven days later,the optic nerve was intraorbitally crushed and each group was injected in the vitreous cavity with normal saline,CNTF,BDNF,or neurotrophins(CNTF and BDNF) ,respectively.The rats were subjected to perfusion fixation according to different time levels,and harvested for stretched slide of the whole retina.At fluoro-microscopy for each slide,four fields 1mm away from the optic papilla were randomly selected,snapshot and calculated for the mean count of FG-labeled surviving RGCs in every field in relation to different agents injected and different time from injury.Results The RGCs in each group decreased over time from optic nerve crush injury.Compared with the control group,the BDNF group,CNTF group and neurotrophins(BDNF and CNTF) group showed frankly higher counts of RGCs at 7,14 and 21 days from injury(P0.01) .The count of RGCs in neurotrophins(BDNF and CNTF) group was consistently higher than those of BDNF group and CNTF group with single use of neurotrophic factor(P0.01) .Conclusion Combined use of neurotrophins(BDNF and CNTF) appears significantly superior to any one of neurotrophic factors(CNTF or BDNF) used alone in the treatment of rat optic nerve lesion." @default.
- W2387683818 created "2016-06-24" @default.
- W2387683818 creator A5002564179 @default.
- W2387683818 date "2007-01-01" @default.
- W2387683818 modified "2023-09-23" @default.
- W2387683818 title "Combined use of neurotrophins for treatment of optic nerve lesion in rats" @default.
- W2387683818 hasPublicationYear "2007" @default.
- W2387683818 type Work @default.
- W2387683818 sameAs 2387683818 @default.
- W2387683818 citedByCount "0" @default.
- W2387683818 crossrefType "journal-article" @default.
- W2387683818 hasAuthorship W2387683818A5002564179 @default.
- W2387683818 hasConcept C118487528 @default.
- W2387683818 hasConcept C126322002 @default.
- W2387683818 hasConcept C134018914 @default.
- W2387683818 hasConcept C142724271 @default.
- W2387683818 hasConcept C160539049 @default.
- W2387683818 hasConcept C169760540 @default.
- W2387683818 hasConcept C170493617 @default.
- W2387683818 hasConcept C2777093970 @default.
- W2387683818 hasConcept C2778423431 @default.
- W2387683818 hasConcept C2778790584 @default.
- W2387683818 hasConcept C2780837183 @default.
- W2387683818 hasConcept C2781156865 @default.
- W2387683818 hasConcept C68710172 @default.
- W2387683818 hasConcept C71924100 @default.
- W2387683818 hasConcept C86803240 @default.
- W2387683818 hasConcept C92020748 @default.
- W2387683818 hasConceptScore W2387683818C118487528 @default.
- W2387683818 hasConceptScore W2387683818C126322002 @default.
- W2387683818 hasConceptScore W2387683818C134018914 @default.
- W2387683818 hasConceptScore W2387683818C142724271 @default.
- W2387683818 hasConceptScore W2387683818C160539049 @default.
- W2387683818 hasConceptScore W2387683818C169760540 @default.
- W2387683818 hasConceptScore W2387683818C170493617 @default.
- W2387683818 hasConceptScore W2387683818C2777093970 @default.
- W2387683818 hasConceptScore W2387683818C2778423431 @default.
- W2387683818 hasConceptScore W2387683818C2778790584 @default.
- W2387683818 hasConceptScore W2387683818C2780837183 @default.
- W2387683818 hasConceptScore W2387683818C2781156865 @default.
- W2387683818 hasConceptScore W2387683818C68710172 @default.
- W2387683818 hasConceptScore W2387683818C71924100 @default.
- W2387683818 hasConceptScore W2387683818C86803240 @default.
- W2387683818 hasConceptScore W2387683818C92020748 @default.
- W2387683818 hasLocation W23876838181 @default.
- W2387683818 hasOpenAccess W2387683818 @default.
- W2387683818 hasPrimaryLocation W23876838181 @default.
- W2387683818 hasRelatedWork W1969811289 @default.
- W2387683818 hasRelatedWork W2035403532 @default.
- W2387683818 hasRelatedWork W2054665308 @default.
- W2387683818 hasRelatedWork W2123964487 @default.
- W2387683818 hasRelatedWork W2350622296 @default.
- W2387683818 hasRelatedWork W2353671003 @default.
- W2387683818 hasRelatedWork W2353733981 @default.
- W2387683818 hasRelatedWork W2363596499 @default.
- W2387683818 hasRelatedWork W2365362875 @default.
- W2387683818 hasRelatedWork W2366935073 @default.
- W2387683818 hasRelatedWork W2374381797 @default.
- W2387683818 hasRelatedWork W2381941491 @default.
- W2387683818 hasRelatedWork W2386313802 @default.
- W2387683818 hasRelatedWork W2388454845 @default.
- W2387683818 hasRelatedWork W2410664833 @default.
- W2387683818 hasRelatedWork W3029126695 @default.
- W2387683818 hasRelatedWork W3031388106 @default.
- W2387683818 hasRelatedWork W3032387989 @default.
- W2387683818 hasRelatedWork W3032621217 @default.
- W2387683818 hasRelatedWork W3084778834 @default.
- W2387683818 isParatext "false" @default.
- W2387683818 isRetracted "false" @default.
- W2387683818 magId "2387683818" @default.
- W2387683818 workType "article" @default.