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- W2387685349 abstract "Objective To investigate the efficacy and safety of pramipexole in the treatment of Parkinson' s disease.Methods A total of 208 Parkinson's patients with wearing off participated in a multi- center,12-weeks randomized,bromocriptine-controlled,double blind,double-dummy and parallel-group trial.The efficacy of pramipexole was assessed according to the patient' s diary card and using the Unified Parkinson's Disease Rating Scale(UPDRS)score,the daily levodopa dosage and the overall evolution of clinical efficacy.The safety was assessed on the basis of adverse events,blood pressure,pulse,laboratory measurements and ECG recordings.Results In 208 cases of the intent-to-treat population,the averaged UPDRS Ⅲ score had decreased to 11.60 in pramipexole(4.5 rag/d)and 10.01 in bromocriptine group (22.5 mg/d),the averaged UPDRS Ⅱ score had decreased to 4.19 and 3.27,respectively,as compared with 12-weeks and base-line,which showed that pramipexole was neither inferior nor superiorit to bromocriptine.Pramipexole was superior to bromocriptine considering that it had more than 30%of patients had changes of UPDRS Ⅱ-Ⅳ scores before and after treatment,a better overall clinic impression evaluated by the researchers and a short time beginning to be effective.The adverse events in a ratio over 5%caused by pramipexole were dizziness,somnolence,nausea,constipation,anorexia,blurred vision,upper abdominal malaise; orthostatic hypotension.No significant difference in terms of the frequencies of adverse events between pramipexole and bromocriptine group.Conclusion Pramipexole should be regarded as an effective and safe treatment for Chinese patients with Parkinson' s disease." @default.
- W2387685349 created "2016-06-24" @default.
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- W2387685349 date "2006-01-01" @default.
- W2387685349 modified "2023-09-22" @default.
- W2387685349 title "Efficacy of pramipexole in the treatment of Parkinson's disease:a multi-center,randomized,double-blind,bromocriptine-control trial" @default.
- W2387685349 hasPublicationYear "2006" @default.
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