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- W2387686871 abstract "Objective To evaluate the prognostic value of serum copeptin levels in patients with respiratory failure. Methods A total of 132 patients who were admitted consecutively between December,2010 and December,2012 at Department of Respiratory,Qianwei Hospital of Jilin Province and Emergency ICU,the First Hospital of Jilin University were recruited. At admission,blood samples were obtained and serum levels of copeptin were measurement with values of various clinical and laboratory variables recorded. On hospitalization day 28,acute physiology and chronic health evaluation Ⅱ( APACHE Ⅱ) scores and simplify acute physiology score Ⅱ( SAPS Ⅱ) scores were obtained for survivors and non- survivors. The correlation of serum levels of copeptin with APACHE Ⅱ and SAPS Ⅱ scores and mortality rate on day 28 was analyzed. Results By hospitalization day 28,41 patients died. Serum levels of copeptin at admission were significantly higher in non- survivors than survivors 〔( 44. 5 ±9. 0) pmol/L vs.( 29. 2 ±12. 0) pmol/L,P 0. 01〕. Both APACHE Ⅱ and SAPSⅡ scores on hospitalization day 28 were positively correlated with serum levels of copeptin at admission( r = 0. 562 and r = 0. 550 respectively). Serum levels of copeptin had an area under the receiver operating characteristic( ROC) curve( AUC) of 0. 840 for predicting 28- day mortality, with 95% CI( 0. 772,0. 907); the optimal cut- off level of copeptin for mortality prediction on day 28 was 34. 5 pmol / L. Serum levels of copeptin higher than 34. 5 pmol / L at admission,APACHE Ⅱ score higher than 17. 5 and SAPS Ⅱ score higher than 30. 5 on hospitalization day 28 were independent predictors of mortality. Conclusion Serum levels of cpeptin at admission are closely correlated with APACHE Ⅱ and SAPS Ⅱ scores on hospitalization day 28 in patients with respiratory failure,thereby having a clinical significance as a potential prognostic factor in this disease population." @default.
- W2387686871 created "2016-06-24" @default.
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- W2387686871 date "2014-01-01" @default.
- W2387686871 modified "2023-09-25" @default.
- W2387686871 title "Clinical Significance of Serum Copeptin on as Potential Prognostic Factor in Patients with Respiratory Failure" @default.
- W2387686871 hasPublicationYear "2014" @default.
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