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- W2387695600 abstract "Objective To analysis the efficacy and safety of combined gemcitabine and S-1 as first-line chemotherapy for patients with locally advanced or metastatic pancreatic cancer. Methods 30 patients with advanced or metastatic pancreatic cancer collected from June 2009 to June 2012 were divided into two groups: group A with 14 patients: The regimen consisted of intravenous 1 000 mg·m- 2gemcitabine on day 1 and 8 combined with oral S-1 on days 1 ~ 14 every four weeks. The dosage of S-1 was based on the body surface area( BSA) as follows: 40 mg bid( total 80 mg·d- 1) for a BSA of 1.25,50 mg bid( total 100 mg·d- 1) for a BSA of ≥1.25 but 1. 5,and 60 mg bid( total 120 mg·d- 1) for a BSA of ≥1.5. group B with 16 patients: intravenous 1 000 mg·m- 2gemcitabine on day 1,8 and 15. The efficacy and side effects were evaluated. Results In group A and group B,the response rate was 46. 2 % and 18.8%( P 0. 05) and the disease control rate was 76. 9 % and 37. 5%( P 0. 05),respectively. the median time to progress of two groups was 4. 4 months and 3. 9 months,and the median overall survival was 9. 4 months and 7. 2 months. The overall survival rate( compared by Log-Rank Cheek) had signifieant difference between two groups( P 0.05). The main toxicity were Hematological toxicity and digestive toxic reactions. there were more leucopenia,nausea and vomiting in group A( P 0. 05). Conclusions The efficacy of S-1 combined with gemcitabine as first-line chemotherapy is superior in the disease control rate for advanced or metastatic pancreatic cancer compared with gemcitabine alone and the side effect are tolerable. It is worthy of further clinical study." @default.
- W2387695600 created "2016-06-24" @default.
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- W2387695600 date "2014-01-01" @default.
- W2387695600 modified "2023-09-26" @default.
- W2387695600 title "ClinicaI research of combined gemcitabine and S-1 as first-line chemotherapy for advanced pancreatic cancer" @default.
- W2387695600 hasPublicationYear "2014" @default.
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