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- W2387702337 abstract "Objective To study the comparative effect of huperzine A and pyridostigmine bromide in preventing poisoning caused by organophosphorous nerve intoxicant.Methods 1.0 mg/kg huperzine A and 5.82 mg/kg pyridostigmine bromide were used as the preventive agent respectively 30 min prior to the paraoxon(2.7 mg/kg)administration.The mortality and scores of salivation,lacrimation,urination and defecation(SLUD)and involuntary movements(IM)were recorded and compared with the control group.Results After given 1.0 mg/kg huperzine A or 5.82 mg/kg pyridostigmine bromide,the mortality of huperzine A and pyridostigmine treatment group were 10.00% and 15.00%,the mortality of the control group was 54.54%,scores of SLUD and IM of the treatment group were lower than that of the control group,the difference was significant(P0.05).No significant difference between two treatment groups was found(P0.05).Conclusions Huperzine A is effective in preventing poisoning caused by organophosphorous nerve intoxicant and its efficacy is equal to that of pyridostigmine bromide." @default.
- W2387702337 created "2016-06-24" @default.
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- W2387702337 date "2008-01-01" @default.
- W2387702337 modified "2023-09-23" @default.
- W2387702337 title "Comparison of Effect of Huperzine A and Pyridostigmine Bromide in Preventing Poisoning Caused by Organophosphorous Nerve Intoxicant" @default.
- W2387702337 hasPublicationYear "2008" @default.
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