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- W2387702987 abstract "Objective To observe the effect of exercise on BDNF,HSP70,and oxidative stress level in prefrontal cortex of depression rat and supply experimental and data supports for further understanding the mechanism of exercise improving depression.Methods 16 Wistar rats were randomly divided into control group and exercise intervention group.Within 4 weeks,rats were given the chronic unpredictable stress to induce the depressive disorder.Besides the chronic unpredictable stress,rats of the exercise intervention group also suffered the low intensity exercise.4 weeks later,we assessed the depression-like behavior.After decapitation,brain was quickly obtained,BDNF,HSP70 and the oxidative stress level in prefrontal cortex was determined.Results Compared with control group,the time of total immobilization decreased in exercise intervention group after 4 weeks exercise intervention(P 0.05).The BDNF level,HSP70 and anti-oxidative capacity of exercise intervention group all increased significantly(P 0.05),while,the MDA content,which represents the oxidative stress level decreased significantly(P 0.05).Conclusions The prefrontal cortex might be one of the important areas that affect depression behavior,and the way it works might through the up-regulation of BDNF,HSP70 and the anti-oxidative capacity." @default.
- W2387702987 created "2016-06-24" @default.
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- W2387702987 date "2013-01-01" @default.
- W2387702987 modified "2023-09-27" @default.
- W2387702987 title "Effect of Exercise on BDNF,HSP70,and Oxidative Stress Level in Prefrontal Cortex of Depression Rat" @default.
- W2387702987 hasPublicationYear "2013" @default.
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