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- W2387709788 abstract "Objective To study the specificity of expression of CD133, CD44 and PSCA in liver cancer,pericarcinomatous liver tissues and HepG2 cells. Methods The immunohistochemistry was used to detect the expression of CD133,CD44 and PSCA in 70 hepatocellular carcinomas( HCC),50 intrahepatic cholangiocarcinomas( ICC) and HepG2 cells. Results In the HCCs,the positive rates of CD133,CD44,PSCA were 58. 6%( 41 /70),61. 4%( 43 /70),40%( 28 /70). In the ICCs,the positive rates were 56%( 28 /50),52%( 26 /50),44%( 22 /50),respectively.The positive expression rates of CD133,CD44 and PSCA had no significant difference in HCCs and ICCs( χ2= 0. 824,P 0. 05),but the intensity of positive expression of PSCA in the ICCs was significantly higher than in HCCs( P 0. 05).The distributions of CD133,CD44,PSCA-positive cells in HCC,ICC and HepG2 cells existed two forms: scattered and clusters /flaky,and the scattered was the main distribution of CD133,while the CD44 and PSCA-positive cells were mainly distributed in clusters /flaky. The positive expression rates of CD133,CD44 and PSCA were 51. 4%( 36 /70),47. 1%( 33/70),32.9%( 23/70) and 46%( 23/50),32%( 16/50),36%( 18/50) in the tissues surrounding HCC and ICC respectively,and the significant difference was not found( P 0. 05) for the expression rates of three kinds of proteins in the tissues nearby HCC and ICC. They for the expression of CD133,CD44,PSCA in the HCC,ICC were obviously consistency in their pericarcinomatous liver tissues. Conclusions CD133,CD44,PSCA might be specific markers of liver carcinoma stem cells,and CD133 might be the most specific surface marker of liver carcinoma stem cells,while PSCA might be the more specific surface markers for ICC." @default.
- W2387709788 created "2016-06-24" @default.
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- W2387709788 date "2014-01-01" @default.
- W2387709788 modified "2023-09-23" @default.
- W2387709788 title "Expression and significance of several candidate markers of tumor stem cell in hepatocellular carcinoma" @default.
- W2387709788 hasPublicationYear "2014" @default.
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