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- W2387712207 abstract "OBJECTIVE:To compare the distribution of virulence-associated genotypes of Helicobacter.pylori in two Chinese populations with contrasting gastric cancer risk and furthermore probe into the pathogenicity of the bacterium. METHODS:Gastric biopsies gastric biopsies were taken from 355 subjects from Zhuanghe, the high risk area of gastric cancer, and 136 subjects from Shenyang, the low risk area of China. A total of 149 H.pylori strains isolated from these patients were studied by PCR for detecting the genotypes of cagA, vacA, and iceA.RESULTS:In patients from the population with high risk for gastric cancer,statistically significant higher relative frequencies of vacA s1 (95.33% vs 64.29%, χ2=25.008,P=0.000) or s1m1b (20.56% vs 2.38%, χ2=7.637,P=0.006) genotypes were found as compared to the population from the low risk area.CONCLUSION:There was significant difference distribution of H.pylori genotypes between Zhuanghe area and Shenyang area. The presence of vacA s1 or vacA s1m1b strain in Zhuanghe is higher than that in Shenyang. Tt is suggested that virulence associated genes of H.pylori may be a factor contributed to the higher gastric cancer incidence rate in the high-risk area compared with the low. In the future, it is necessary to make deeply research at this strain. It will give a clue to make sure the bacterial mechanisam." @default.
- W2387712207 created "2016-06-24" @default.
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- W2387712207 date "2006-01-01" @default.
- W2387712207 modified "2023-09-26" @default.
- W2387712207 title "Geographical characteristics of Helicobacter.pylori genotypes strain in the high and low-risk areas of gastric cancer" @default.
- W2387712207 hasPublicationYear "2006" @default.
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