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- W2387713897 abstract "Objective To evaluate and compare the anti-epileptic effects of N-methyl-D-aspartate(NMDA) receptor antagonists dizocilpine(MK-801) and diazepam(DZP)which acts on γ-aminobutyric acid(GABA) system on tetramine(TET)-induced refractory epilepsy(RE)in rats.Methods Upon the establishment of TET-induced RE in rats,the anti-epileptic effect and neuroprotection of MK-801(3 and 5 mg/kg)and DZP(10 and 20 mg/kg)on TET-induced RE and brain injury were examined by behavior,EEG and HE-staining.Using real-time quantitative polymerase chain reaction(RT-PCR) and Western blotting,the effect of MK-801(5 mg/kg)and DZP(20 mg/kg)on the expression of NR2A/2B mRNA and corresponding proteins was tested.Results MK-801(3,5 mg/kg)showed better anti-epileptic and neuroprotective effects on TET-induced RE and brain injury than DZP.Furthermore,the mRNA and corresponding proteins of NR2A/2B were down-regulated obviously in MK-801(5 mg/kg)treatment groups while the expression of NR2A/2B remained unchanged in DZP(20 mg/kg)treatment group.Conclusion MK-801 can effectively inhibit the RE and brain injury caused by TET;its inhibitive effects may be related to the down-regulating effects on the expression of NR2A/2B receptor." @default.
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- W2387713897 date "2012-01-01" @default.
- W2387713897 modified "2023-09-26" @default.
- W2387713897 title "Anti-epileptic effect of dizocilpine on refractory epilepsy induced by tetramine in rats" @default.
- W2387713897 hasPublicationYear "2012" @default.
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