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• W2387721648 abstract "Bagirsak mikrobiyotasi beyin ve bagirsak arasinda karsilikli bir iliski olusturarak insan sagligi uzerin- de temel ve onemli bir rol oynar. Obesite, diyabet gibi metabolik hastaliklar ve sizofreni, otizm, anksiyete, depresyon gibi neuropsikiyatrik bozukluklarla bagirsak mikrobiyotasi arasinda baglanti olduguna iliskin guclu kanitlar vardir. Yeni arastirmalar gastrointestinal sistemde yasayan dost, zararli ve probiyotik mikroorganizmalarin bagisiklik sistemini, noral yolaklari ve pesi sira merkezi sinir sistemini uyardigini ortaya koymaktadir. Bu mikroorganizmalar bagirsak beyin ekseninde rol oynayan gama-aminobutirik asit ve serotonin gibi noroaktif maddeleri uretmektedir. Preklinik hayvan deneyleri bazi probiyotik bakterilerin anksiyolitik ve antidepresan etkiye sahip oldugunu gostermektedir. Bu makalede bagirsak mikrobiyotasinin beyin, davranis ve psikiyatrik bozukluklar uzerine etkisi gozden gecirilmistir. Anahtar sozcukler: Bagirsak-beyin ekseni, mikrobiyota, psikiyatrik bozukluklar. Abstract Gut microbiota is essential to human health, playing a major and important role in the bidirectional communication between the gut and the brain. There is significant evidence linking gut microbiota and metabolic disorders such as obesity, diabetes and neuropsychiatric disorders such as schizo- phrenia, autism, anxiety, depression. New studies show microbiota can activate immune system, neural pathways and central nervous system signaling systems, including commensal, probiotic and pathogenic microorganisms in the gastrointestinal tract. This microorganisms are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid and serotonin, which act on the gut-brain axis. Preclinical evaluation in rodents suggests that certain probiotics possess antidepressant or anxiolytic activity. Effects may be mediated via the vagus nerve, spinal cord, immune system or neuroendocrine systems. Here we review recent literature that examines the impact of gut microbiota on the brain, behavior and psychiatric disorders." @default.
• W2387721648 created "2016-06-24" @default.
• W2387721648 creator A5051428909 @default.
• W2387721648 creator A5082424926 @default.
• W2387721648 date "2015-01-01" @default.
• W2387721648 modified "2023-09-24" @default.
• W2387721648 title "Bağirsak Beyin Ekseni: Psikiyatrik Bozukluklarda Bağirsak Mikrobiyotasinin Rolü-Brain Axis: The Role of Gut Microbiota in Psychiatric Disorders" @default.
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