Matches in SemOpenAlex for { <https://semopenalex.org/work/W2387743551> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2387743551 abstract "OBJECTIVE:To prepare and evaluate the quality of Quetiapine fumarate solid lipid nanoparticles(QF-SLN)in situ nasal gel.METHODS:With the oil phase of dissoned glycerin monostearate,emulsifier of sorbitan oleate,and co-emulsifier of n-butyl alcohol,the proportion of emulsifier and co-emulsifier(Km)was screened by ternary phase diagrams.QF-SLN was prepared through the micro-emulsion technology,the gelling temperature was set as index,the mass fraction of poloxamerln 407(P407)and P188 of in situ gel formulation was optimized by the central composite design-response surface methodology.in situ formation of QF-SLN was examined by transmission electron microscope,the particle size and potential distribution were determined by Malvern laser granularity equipment,and the encapsulation efficiency and stability were determined by the ultrafiltration centrifuge tube and HPLC.RESULTS:The formulation of solid lipid nanoparticlesl was biggest at Km=1 ∶ 9.The optimized formulation was with 21% P407,5.6% P188 and 73.4% water.The prepared QF-SLN in situ nasal gel was uniform sphere,with an average particle size of(136.3±6.4)nm and encapsulation efficiency of(97.60±0.48)%.There were no obvious changes in the particle size and entrapment efficiency at 4 ℃ within one month.CONCLUSIONS:The QF-SLN in situ nasal gel is successfully prepared." @default.
- W2387743551 created "2016-06-24" @default.
- W2387743551 creator A5021020705 @default.
- W2387743551 date "2015-01-01" @default.
- W2387743551 modified "2023-09-25" @default.
- W2387743551 title "Preparation and Quality Control of Quetiapine Fumarate Solid Lipid Nanoparticles in situ Nasal Gel" @default.
- W2387743551 hasPublicationYear "2015" @default.
- W2387743551 type Work @default.
- W2387743551 sameAs 2387743551 @default.
- W2387743551 citedByCount "0" @default.
- W2387743551 crossrefType "journal-article" @default.
- W2387743551 hasAuthorship W2387743551A5021020705 @default.
- W2387743551 hasConcept C101335993 @default.
- W2387743551 hasConcept C11432220 @default.
- W2387743551 hasConcept C127413603 @default.
- W2387743551 hasConcept C147789679 @default.
- W2387743551 hasConcept C15920480 @default.
- W2387743551 hasConcept C178790620 @default.
- W2387743551 hasConcept C185592680 @default.
- W2387743551 hasConcept C187530423 @default.
- W2387743551 hasConcept C192562407 @default.
- W2387743551 hasConcept C199529486 @default.
- W2387743551 hasConcept C2777822432 @default.
- W2387743551 hasConcept C2778123984 @default.
- W2387743551 hasConcept C2780306666 @default.
- W2387743551 hasConcept C42360764 @default.
- W2387743551 hasConcept C43617362 @default.
- W2387743551 hasConcept C521977710 @default.
- W2387743551 hasConcept C60448018 @default.
- W2387743551 hasConceptScore W2387743551C101335993 @default.
- W2387743551 hasConceptScore W2387743551C11432220 @default.
- W2387743551 hasConceptScore W2387743551C127413603 @default.
- W2387743551 hasConceptScore W2387743551C147789679 @default.
- W2387743551 hasConceptScore W2387743551C15920480 @default.
- W2387743551 hasConceptScore W2387743551C178790620 @default.
- W2387743551 hasConceptScore W2387743551C185592680 @default.
- W2387743551 hasConceptScore W2387743551C187530423 @default.
- W2387743551 hasConceptScore W2387743551C192562407 @default.
- W2387743551 hasConceptScore W2387743551C199529486 @default.
- W2387743551 hasConceptScore W2387743551C2777822432 @default.
- W2387743551 hasConceptScore W2387743551C2778123984 @default.
- W2387743551 hasConceptScore W2387743551C2780306666 @default.
- W2387743551 hasConceptScore W2387743551C42360764 @default.
- W2387743551 hasConceptScore W2387743551C43617362 @default.
- W2387743551 hasConceptScore W2387743551C521977710 @default.
- W2387743551 hasConceptScore W2387743551C60448018 @default.
- W2387743551 hasLocation W23877435511 @default.
- W2387743551 hasOpenAccess W2387743551 @default.
- W2387743551 hasPrimaryLocation W23877435511 @default.
- W2387743551 hasRelatedWork W1502613167 @default.
- W2387743551 hasRelatedWork W1971246163 @default.
- W2387743551 hasRelatedWork W1982759704 @default.
- W2387743551 hasRelatedWork W2050063412 @default.
- W2387743551 hasRelatedWork W2138395810 @default.
- W2387743551 hasRelatedWork W2360965849 @default.
- W2387743551 hasRelatedWork W2366519761 @default.
- W2387743551 hasRelatedWork W2372253000 @default.
- W2387743551 hasRelatedWork W2376351669 @default.
- W2387743551 hasRelatedWork W2382530173 @default.
- W2387743551 hasRelatedWork W2384014580 @default.
- W2387743551 hasRelatedWork W2385061581 @default.
- W2387743551 hasRelatedWork W2393416637 @default.
- W2387743551 hasRelatedWork W2548838368 @default.
- W2387743551 hasRelatedWork W3030920074 @default.
- W2387743551 hasRelatedWork W3037554283 @default.
- W2387743551 hasRelatedWork W3109465235 @default.
- W2387743551 hasRelatedWork W3114380273 @default.
- W2387743551 hasRelatedWork W3199906896 @default.
- W2387743551 hasRelatedWork W2471892529 @default.
- W2387743551 isParatext "false" @default.
- W2387743551 isRetracted "false" @default.
- W2387743551 magId "2387743551" @default.
- W2387743551 workType "article" @default.