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- W2387746761 abstract "In order to explore the morphogenesis linked to the replicating mechanism of SARS-associated coronavirus(SARS-CoV),a comprehensive electron microscopy(EM),including negative staining,ultra-thin sectioning and immune colloidal gold EM,was made in fully use.A striking polymorphism of the SARS-CoV both in shape and size in Vero cell cultures attracted the authors' attention.The size variation was remarkable ranking from 400nm to 20nm,with size decreasing tendency in immature or provirions parallel to the increasing of density in mature virions.The mature virions were more or less spherical in appearance.They were morphologically identical to the ordinary coronaviruses,whereas,the variation of the immature virions was more eminent.Along with the ordinary ones,there were some aberrant particles dispersing within the cytoplasm of the infected cells such as kidney-like,dumb bell-like,and nail-like particles.Occasionally,branch-like virions were also distinctly seen.What was more,some unusual figure of the nucleoprotein-like structures could be visualized in the cytoplasmic matrix of the infected cells.This structure looked like zigzag,most probably representing the helix of the genomic component of the virus." @default.
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- W2387746761 date "2006-01-01" @default.
- W2387746761 modified "2023-09-26" @default.
- W2387746761 title "Morphological Polymorphism of SARS-CoV in Vero Cell Cultures" @default.
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