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- W2387749503 abstract "OBJECTIVE To explore the diagnostic role of soluble triggering receptor expressed on myeloid cells-1(sTREM-1) in ventilator associated pneumonia(VAP).METHODS Levels of sTREM-1 in serum and endotracheal aspirate(ETA) were measured by enzyme-linked immunosorbent assay(ELISA),meanwhile C-reactive protein(CRP),Clinical pulmonary infection score(CPIS) were examined before treatment,after 5 days therapy and 10 days therapy respectively in three groups.RESULTS In VAP group,levels of sTREM-1 in serum and ETA,CPIS and CRP increased significantly before treatment than 5 days therapy and 10 days therapy,there was a significant difference compared with other groups(P0.01).After 10 days therapy,sTREM-1,CPIS and CRP had no difference between VAP group and non-VAP group(P0.05).Receiver operating characteristic(ROC) curve was analyzed,if 172 pg/ml sTREM-1 in ETA was selected to be a break point of the diagnosis of VAP,sensitivity was 86.7% and specificity was 84.6%.CONCLUSION Level of sTREM-1 in ETA is a potential diagnostic biomarker of VAP when level of sTREM-1 increases to 172ng/ml.The sensitivity and specificity of the diagnosis of VAP are both high.The level of sTREM-1 in ETA decreases towards normal level quickly after antibiotic treatment.sTREM-1 in ETA can be a tool to judge the therapeutic effect." @default.
- W2387749503 created "2016-06-24" @default.
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- W2387749503 date "2011-01-01" @default.
- W2387749503 modified "2023-09-25" @default.
- W2387749503 title "Clinical significance of soluble triggering receptor expressed on myeloid cell-1 in diagnosis of ventilator-associated pneumonia" @default.
- W2387749503 hasPublicationYear "2011" @default.
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