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- W2387758411 abstract "Objective To explore the state of clozapine induced arrhythmia and its associated clinical risk factors.Method 500 inpatients were treated with clozapine and measured heart rate,heart rhythm,cardiac conduction changes before and after treatment.We compared the clinical factors,such as age,sex,pre-medication,co-medication,pre-existing cardiovascular disease,patients' physical condition before the therapy,duration of applied clozapine and therapeutic doses etc.,between the patients with and without arrhythmia.Results There are 61 patients(12.2%) that showed clinically significant arrhythmia(one of the following in: ①Heart rate ≥140 beats / min or a heart rate ≥130 beats/min and T wave abnormalities;②There is frequent premature beats(≥ 3 times/min),severe heart rhythm changes;③Cardiac conduction disturbances) after treatment with clozapine.The major clinical factors associated with this side effect were as follows: higher plasma clozapine concentration,higher dose of clozapine,the beginning of treatment and co-administration of several psychotropic drugs(≥3 species).Conclusions Clozapine might induce clinical significant arrhythmia in patients,which suggest that clozapine is not suitable to be used as the first-line psychotropic drug,and it is necessary to monitor its electrocardiogram strictly." @default.
- W2387758411 created "2016-06-24" @default.
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- W2387758411 date "2011-01-01" @default.
- W2387758411 modified "2023-09-24" @default.
- W2387758411 title "The Investigation Into the Clinical Risk Factors of Clozapine induced Arrhythmia" @default.
- W2387758411 hasPublicationYear "2011" @default.
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