Matches in SemOpenAlex for { <https://semopenalex.org/work/W2387758975> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2387758975 endingPage "21" @default.
- W2387758975 startingPage "618" @default.
- W2387758975 abstract "To study the alteration of the expression of CD28 on CD4 + T cells in HIV/AIDS patients and observe the dynamics of CD28 expression under highly active antiretroviral therapy (HAART).The expression of CD28 on CD4 + T cells, CD4 counts, and plasma viral load were measured by flow cytometry and bDNA assays in 278 treatment-naïve HIV/AIDS patients and 56 healthy controls. In addition, the evolution of these parameters was assessed in 59 patients who initiated HAART and were followed for 12 months in regular 3-month visits.The median level of CD28 on CD4 + T cells decreased dramatically in treatment-naïve HIV-positive individuals than in HIV-negative controls (P <0.001). The expression rate of CD28 molecule was positively correlated with CD4 counts (r = 0.484, P < 0.001), and negatively correlated with plasma viral load (r = -0.300, P <0.001). In patients who had received one month of standard HAART, the level of CD28 on CD4 + T cells increased rapidly from 75.0% to 90.0% (P < 0.001). Moreover, there was a negative correlation between the median CD28 expression and the median viral load (r = - 0.829, P = 0.042).The level of CD28 expression on CD4 + T cells is down-regulated in treatment-naïve HIV/AIDS patients. HAART can successfully restore the lymphocyte subsets of CD4 + CD28 + T cells. The up-regulation of CD28 expression after HAART may be closely correlated with the suppression of the viral replication." @default.
- W2387758975 created "2016-06-24" @default.
- W2387758975 creator A5008857498 @default.
- W2387758975 creator A5025546736 @default.
- W2387758975 creator A5028609590 @default.
- W2387758975 creator A5040440297 @default.
- W2387758975 creator A5044459845 @default.
- W2387758975 creator A5071269002 @default.
- W2387758975 creator A5078648753 @default.
- W2387758975 date "2006-10-01" @default.
- W2387758975 modified "2023-09-29" @default.
- W2387758975 title "[Abnormal changes of CD28 expression on CD4 + T cells in treatment-näive and highly active antiretroviral therapy-treated HIV/AIDS patients]." @default.
- W2387758975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17121217" @default.
- W2387758975 hasPublicationYear "2006" @default.
- W2387758975 type Work @default.
- W2387758975 sameAs 2387758975 @default.
- W2387758975 citedByCount "0" @default.
- W2387758975 crossrefType "journal-article" @default.
- W2387758975 hasAuthorship W2387758975A5008857498 @default.
- W2387758975 hasAuthorship W2387758975A5025546736 @default.
- W2387758975 hasAuthorship W2387758975A5028609590 @default.
- W2387758975 hasAuthorship W2387758975A5040440297 @default.
- W2387758975 hasAuthorship W2387758975A5044459845 @default.
- W2387758975 hasAuthorship W2387758975A5071269002 @default.
- W2387758975 hasAuthorship W2387758975A5078648753 @default.
- W2387758975 hasConcept C126322002 @default.
- W2387758975 hasConcept C140704245 @default.
- W2387758975 hasConcept C142462285 @default.
- W2387758975 hasConcept C148125776 @default.
- W2387758975 hasConcept C151678543 @default.
- W2387758975 hasConcept C203014093 @default.
- W2387758975 hasConcept C2522874641 @default.
- W2387758975 hasConcept C2776090121 @default.
- W2387758975 hasConcept C2993143319 @default.
- W2387758975 hasConcept C3013748606 @default.
- W2387758975 hasConcept C553184892 @default.
- W2387758975 hasConcept C71924100 @default.
- W2387758975 hasConcept C8891405 @default.
- W2387758975 hasConceptScore W2387758975C126322002 @default.
- W2387758975 hasConceptScore W2387758975C140704245 @default.
- W2387758975 hasConceptScore W2387758975C142462285 @default.
- W2387758975 hasConceptScore W2387758975C148125776 @default.
- W2387758975 hasConceptScore W2387758975C151678543 @default.
- W2387758975 hasConceptScore W2387758975C203014093 @default.
- W2387758975 hasConceptScore W2387758975C2522874641 @default.
- W2387758975 hasConceptScore W2387758975C2776090121 @default.
- W2387758975 hasConceptScore W2387758975C2993143319 @default.
- W2387758975 hasConceptScore W2387758975C3013748606 @default.
- W2387758975 hasConceptScore W2387758975C553184892 @default.
- W2387758975 hasConceptScore W2387758975C71924100 @default.
- W2387758975 hasConceptScore W2387758975C8891405 @default.
- W2387758975 hasIssue "5" @default.
- W2387758975 hasLocation W23877589751 @default.
- W2387758975 hasOpenAccess W2387758975 @default.
- W2387758975 hasPrimaryLocation W23877589751 @default.
- W2387758975 hasRelatedWork W172728499 @default.
- W2387758975 hasRelatedWork W1976973185 @default.
- W2387758975 hasRelatedWork W1995664428 @default.
- W2387758975 hasRelatedWork W2009261425 @default.
- W2387758975 hasRelatedWork W2013375106 @default.
- W2387758975 hasRelatedWork W2020054062 @default.
- W2387758975 hasRelatedWork W2027970569 @default.
- W2387758975 hasRelatedWork W2076302300 @default.
- W2387758975 hasRelatedWork W2083459010 @default.
- W2387758975 hasRelatedWork W2084007270 @default.
- W2387758975 hasRelatedWork W2099160001 @default.
- W2387758975 hasRelatedWork W2128367584 @default.
- W2387758975 hasRelatedWork W2132735695 @default.
- W2387758975 hasRelatedWork W2352638479 @default.
- W2387758975 hasRelatedWork W2369153231 @default.
- W2387758975 hasRelatedWork W2378505325 @default.
- W2387758975 hasRelatedWork W2378809130 @default.
- W2387758975 hasRelatedWork W2463093113 @default.
- W2387758975 hasRelatedWork W1958968825 @default.
- W2387758975 hasRelatedWork W3146520959 @default.
- W2387758975 hasVolume "28" @default.
- W2387758975 isParatext "false" @default.
- W2387758975 isRetracted "false" @default.
- W2387758975 magId "2387758975" @default.
- W2387758975 workType "article" @default.