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- W2387767874 abstract "Objective To observe the therapeutic effect of CDglyTK gene mediated by radiation-inducible promoters in the treatment of Xenograft of human tongue squamous carcinoma in nude mice.Methods The model of transplanted Tca8113 cell line in nude mice was established.The plasmids pcDNA(+)3.1 /E-CDglyTK were transfected into tumors by lipofectamine.24 h later,the tumors were exposed to 3 Gy irradiation,and then 5-fluorocytosine(5-FC) and ganciclovir(GCV) were injected into nude mice at intervals.Animals were examed at regular intervals for tumor volume.CDglyTK mRNA was assayed by RT-PCR.Apoptosis and proliferating cell nuclear antigen were detected respectively by in situ end-labeling and immunohistiochemical method.Results Compared with control groups,the tumor was suppressed obviously by CDglyTK gene therapy combined with 3 Gy induction radiation.The expression of CDglyTK gene could be detected by RT-PCR in the transfected tumor,and up-regulation of CDglyTK expression was found in tumor exposed to radiation(P 0.01).There was significant difference between the apoptosis index or proliferation index in tumor without irradiation and that in tumor with irradiation(P 0.01).Conclusions The radiation-inducible promoter can be served as a molecular switch to improve the expression of CDglyTK gene in transplanted human tongue squamous carcinoma in nude mice,and low dose induction radiation can significantly improve the therapeutic efficiency." @default.
- W2387767874 created "2016-06-24" @default.
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- W2387767874 date "2009-01-01" @default.
- W2387767874 modified "2023-09-26" @default.
- W2387767874 title "Radiation-inducible promoters mediated CDglyTK gene in the treatment of Xenograft of human tongue squamous cell carcinoma in naked mice" @default.
- W2387767874 hasPublicationYear "2009" @default.
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