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- W2387788166 abstract "In order to evaluate the safety and efficacy of the inactivated rabies vaccine(strain CTN-1) produced by Tangshan Yian Biological Engineering Co.,Ltd,five batches of the vaccine were applied for field trials in Beijing area.Clinical observations indicated the vaccine was safety and stability without side effects in vaccinated dogs.The antibody assays showed that 97.5% inoculated dogs developed neutralizing antibody and the antibody levels in 90% dogs exceed the protective threshold value(0.5 IU/mL) after 7 days post immunization(PI),afterward,the protective threshold of neutralizing antibody titer was 90.5% at 360 days and 83% at 390 days in vaccinated dogs PI.In addition,thirty vaccinated dogs at 390 days PI were randomly selected and challenged with street rabies virus CNX8511 strain,with the positive control of 10 dogs immunized with the vaccine manufactured by Intervet International Co.,Ltd and 10 unvaccinated dogs as negative control,the results displayed that all immunized dogs were fully protected during 90 days of experiment period,whereas,all dogs in control group died within 18 to 30 days post challenge.The studies demonstrated that the rabies vaccine(strain CTN-1) for animals had an equal or even better immune efficacy compared to the commercial vaccine and was suitable for animal rabies control program in China." @default.
- W2387788166 created "2016-06-24" @default.
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- W2387788166 date "2013-01-01" @default.
- W2387788166 modified "2023-09-25" @default.
- W2387788166 title "Efficacy of the inactivated rabies vaccine(CTN-1 strain) in field trials" @default.
- W2387788166 hasPublicationYear "2013" @default.
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