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- W2387788204 abstract "Objective To investigate the feasibility,efficacy and toxicity of consolidation chemotherapy based on three dimensional conformal radiotherapy and synchronized chemotherapy in patients with non-small cell lung cancer (NSCLC). Methods 106 patients with stage III NSCLC were randomly divided into two groups:consolidation radio-chemotherapy group (study group) and radio-chemotherapy group (control group). Radiotherapy was given with three-dimensional conformal technology. The total dose was DT:60-66Gy (2Gy/f) for primary lung lesions or mediastinal lymph node (≥1cm). Metastatic lymph node in supraclavicular region was given 6MV-X combined electron ray by conventional fractionation radiotherapy until the total dose reached DT:60 -66Gy. The NP regimen was used for chemotherapy,given in 2 cycles for the control group and in 4 cycles for the study group. The timing of chemotherapy cycles in the control group was the first week and the last week during radiotherapy period. As for the study group,two more cycles were given after synchronized radio-chemotherapy as in the control group. Results 101 patients completed the treatment protocol. 75.4% and 84.9% of the patients in the control group and study group,respectively,respond-ed to the treatment. In the control group,the 1-,2-and 3-year survival rate was 71.6%,41.5% and 28.3%,the median length of survival was 14.2 months,the 1-,2-and 3-year progression-free survival (PFS) rate was 60.3%,33.9% and 18.8%,and the median relapse-free survival period (RSFP) was 10.6-months. These figures compared with 77.3%,49.1% and 33.9% for 1-,2-and 3-year survival rate,17.9 months for median length,67.9%,37.7% and 24.5% for the 1-,2-and 3-year PFS rates and 12.3 months for RFSP in the study group. The reported acute toxicity events included bone marrow depression,gastrointestinal reaction,acute radiation esophagitis,radiation bronchitis and pneumo-nia,which seemed to be more frequent with consolidation chemotherapy. Conclusion Consolidation chemotherapy based on three dimensional conformal radiotherapy combined with synchronized chemotherapy may not increase the survival rate for NSCLC patients." @default.
- W2387788204 created "2016-06-24" @default.
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- W2387788204 date "2009-01-01" @default.
- W2387788204 modified "2023-09-24" @default.
- W2387788204 title "The clinical study of consolidative chemotherapy based on synchronized radio-chemotherapy in patients with non-small cell lung cancer" @default.
- W2387788204 hasPublicationYear "2009" @default.
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