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- W2387788802 abstract "Endothelial-mesenchymal transition(EndMT),a newly recognized type of cellular transition,is a specific form of epithelial-mesenchymal transition,and has been demonstrated to participate in biological and pathological process.This so-called mesenchymal phenotype can be characterized by loss of cell-cell junctions,acquisition of highly invasive and migratory properties,loss of endothelial specific markers,such as CD31(also known as platelet endothelial cell adhesion molecule-1,PECAM-1)and VE-cadherin,and gain of mesenchymal markers,such as fibroblast-specific protein 1(FSP1,also known as S100A4) or α-smooth muscle actin(α-SMA),alteration in cytoskeletal composition and organization to induce a striking change in cell morphology that forms elongated,spindle-shaped cells.Previous studies showed that EndMT was a critical process of embryonic cardiac development.Emerging evidence in recent years shows,endothelial-mesenchymal transition participate in a number of diseases,including pulmonary,intestinal,cardiac,and kidney fibrosis,idiopathic portal hypertension,atherosclerosis,pulmonary hypertension,tumors and so forth.However,little is known about the signaling mechanisms that cause endothelial cells to transform into mesenchymal cells.Transforming growth factor-β,Notch,Wnt,microRNAs or other signaling pathways and cytokines could direct or interact to mediate EndMT.Therefore,to address its potential mechanisms of EndMT may provide novel therapeutic strategies for treating diseases." @default.
- W2387788802 created "2016-06-24" @default.
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- W2387788802 date "2013-01-01" @default.
- W2387788802 modified "2023-09-24" @default.
- W2387788802 title "Signal Mechanism of Endothelial-Mesenchymal Transition" @default.
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