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- W2387792784 abstract "OBJECTIVE: To evaluate the quality of Nofloxacin polybutylcyanoacylate nanoparticles(NFLX--PBCA--NP) inrespect to the morphology, size and size distribution, drug loading, release characteristics in vitro, stability and safty.METHODS:To observe the morphology and size by TEM and laser particle size analyzer; to determine the embedding rate anddrug loading by UV- spectrophotometry; to measure the drug release in vitro by dynamic dialysis; to evaluate the stability byobserving the changes of drug contents and hygienic parameters and to observe the irritability by eye irritation test. RESULTS CONCLUSION: The results showed that the mean size was dav= 553um, embedding ratio was 90. 14%, drug loading was22. 70%. The release characteristic in vitro was in accord with two phases kinetics law. The embedding concentration was stableafter 3 months storage. The drug has no irritation to the eyes." @default.
- W2387792784 created "2016-06-24" @default.
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- W2387792784 date "1999-01-01" @default.
- W2387792784 modified "2023-09-23" @default.
- W2387792784 title "The Study on the Quality of Ophthalmic NFLX-PBCA-NP" @default.
- W2387792784 hasPublicationYear "1999" @default.
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