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- W2387796359 abstract "AIM: To explore the method of 188 Re direct labeling of angiostatin (AS) and investigate the stability of 188 Re -AS in vitro and its distribution in mice.METHODS: AS was synthesized, validated, then labeled with 188 Re after being reduced by SnCl2. Labeling efficiency was measured by paper chromatography. The stability of 188 Re-AS was observed when BSA, saline and different molar ratios of Cys: AS was added separately. RESULTS: The labeled efficiency can reach 76.3% for the SnCl2-reduced approach. The best experimental condition was described below: AS100 μg,20 g/L SnCl2 (dissolved in 1 mol/L hydrochloric acid)200 μL, 0.1 mol/L sodium tartrate (dissolved in 0.05 mol/L hydrochloric acid), and then 188 ReO4-37 MBq was added. There was high liver and kidney uptake and the radiotracer excreted through renal. CONCLUSION: 188 Re direct labeling of AS is simple and efficient. 188 Re-AS is stable in vitro." @default.
- W2387796359 created "2016-06-24" @default.
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- W2387796359 date "2005-01-01" @default.
- W2387796359 modified "2023-09-26" @default.
- W2387796359 title "Preparation of ~(188)Re-AS and its distribution in mice" @default.
- W2387796359 hasPublicationYear "2005" @default.
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