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- W2387800144 abstract "Objective To investigate the expression of haptoglobin in lesional and perilesional nor-mal-appearing skin in psoriasis at mRNA and protein levels,in order to elucidate its relationship to Langer-hans cells and roles in psoriasis.Methods The expression of haptoglobin was detected by immunohisto-chemistry,double labeling immunofluorescence and in situ hybridization in lesional and perilesional normal-appearing skin in psoriatic patients.Results Compared with normal skin,haptoglobin mRNA in ker-atinocytes was significantly increased in psoriatic lesions(P0.001).However,there was no significant dif-ference of haptoglobin mRNA expression between perilesional normal-appearing skin and normal skin(P0.05).Immunohistochemical study showed that some keratinocytes in the lesions could synthesize hap-toglobin,and that haptogolobin was observed in some epidermal Langerhans cells in both lesional and perile-sional normal-appearing skin.The ratios of haptoglobin positive Langerhans cells to total Langerhans cells were significantly increased in both lesional and perilesional normal-appearing skin compared to normal con-trols(P0.001).Conclusions There is increased expression of haptoglobin mRNA and haptoglobin by ker-atinocytes in psoriatic lesions.Haptoglobin-synthesizing keratinocytes might play a role of negative feedback regulation in the pathogenesis of psoriasis." @default.
- W2387800144 created "2016-06-24" @default.
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- W2387800144 date "2004-01-01" @default.
- W2387800144 modified "2023-09-26" @default.
- W2387800144 title "Studies on Haptoglobin Expression in Lesional and Normal-appearing Perilesional Skin in Psoriasis" @default.
- W2387800144 hasPublicationYear "2004" @default.
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