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- W2387807595 abstract "Objective[WT5”BZ] To elucidate the dynamic changes of hydroxyl radical (·OH) and apoptosis in a rat liver preservation-reperfusion model, analyse their interrelations and the protective effects of salvia miltiorrhiza.[WT5”HZ]Methods[WT5”BZ] Using isolated nonrecirculated perfusion rat liver model, we observed the preservation effect of control group (with lactate Ringer's solution),DS group (with lactate Ringer's solution added with salvia miltiorrhiza) and normal group(without preservation) by measuring the content of dihydroxybenzoic acid (DHBA) which was formed after reaction of ·OH with salicylic acid,apoptosis index(AI) and the expression index of Bcl-2 protein(BI).[WT5”HZ]Results[WT5”BZ] ·OH levels expressed as DHBAs, and AI enhanced markedly as the time of preservation prolonged. There was a significantly positive correlation between DHBA contents and AI.Both parameters in DS group were significantly lower than those in control group with the same preservation time ( P 0 05). The dynamic changes of BI were just on the contrary when comparing with both parameters.[WT5”HZ]Conclusions[WT5”BZ] ·OH and apoptosis both participate in liver preservation-reperfusion injury, and salvia miltiorrhiza may play an important role on alleviating this injury by a mechanism which correlates to the effect of resisting free radical, inhibiting the occurrence of apoptosis and enhancing the expression of Bcl-2 protein. [WT5”HZ]" @default.
- W2387807595 created "2016-06-24" @default.
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- W2387807595 date "2000-01-01" @default.
- W2387807595 modified "2023-09-23" @default.
- W2387807595 title "The relationship between hydroxyl radical contents,apoptosis and expression of Bcl-2 protein and the protection of salvia miltiorrhiz in a rat liver preservation-reperfusion model" @default.
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