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- W2387813891 abstract "Background: Visceral hypersensitivity is one of the most important pathogenetic mechanisms of irritable bowel syndrome (IBS). Clinically, there is no objective or non-invasive method available for evaluation of visceral sensitivity. Aims: To develop a technique to evaluate spinal evoked potentials (SEP) in response to balloon distension of the rectum, and to obtain the objective evidence of visceral hypersensitivity by comparing the parameters of SEP detected in male and female visceral hypersensitivity rats with IBS and the normal controls. Methods: SEP was recorded after repeated rectal stimulation with rhythmic inflation and deflation of rectal balloon in corresponding segments of spinal cord (L6-S2). Results: In comparison with the controls of the same gender, shorter latencies and greater peak-to-peak amplitudes of SEP were shown among visceral hypersensitivity rats (P0.05 and P0.01). Shorter latencies and lower peak-to-peak amplitudes of SEP were depicted among female rats with visceral hypersensitivity as compared with those of the male rats (P0.05), while no significant differences in latencies and peak-to-peak amplitudes of SEP were found between male and female controls. Conclusions: Reproducible and recognizable SEP can be recorded in response to rhythmically rectal balloon distension, which can provide objective evidence of visceral sensitivity." @default.
- W2387813891 created "2016-06-24" @default.
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- W2387813891 date "2004-01-01" @default.
- W2387813891 modified "2023-09-26" @default.
- W2387813891 title "Study on Spinal Evoked Potentials of Visceral Hypersensitivity in Rats with Irritable Bowel Syndrome" @default.
- W2387813891 hasPublicationYear "2004" @default.
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