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- W2387846552 abstract "The sensitivity of tumor cells to 12 cytostatic preparations was defined in vitro MTT-assay at the 49 resistant and 14 previously untreated CLL patients: untreated patients’ relations of sensitive/assessed were higher than resistant ones’ (0,82 ± 0,03 and 0,5 ± 0,08; ð<0,05). It was shown that more effective agent on resistant patients was sarcolysin (72,7 %). We treated 21 resistant CLL patients with sarcolysin and 58,2 % pts achieved response. 63,6 % among more sensitive pts achieved response in MTT-assay (n=11; LD50 = 2,41 ± 0,9 mgk/ml). 33,3 % among lesser sensitive pts achieved response in MTT-assay (n=6; LD50 = 8,3 ± 2,1 mgk/ml; p<0,05). Overall survival significantly differed between two groups, in the group with chemotherapy of sarcolysin median duration was 80 month, and that was higher then the control — 53 month (p=0,19)." @default.
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- W2387846552 date "2004-01-01" @default.
- W2387846552 modified "2023-09-27" @default.
- W2387846552 title "IN VITRO PHARMACODYNAMIC MODELING OF SARCOLYSIN AND ITS CLINICAL EFFECTIVENESS IN PATIENTS WITH RESIS- TANT CHRONIC LYMPHOCYTIC LEUKEMIA" @default.
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