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- W2387848892 abstract "Objective To discuss the immunosuppressive action of rapamycin which is a new kind of immunosuppressive agent in acute and chronic extensive graft versus host disease after allogeneic hematopoietic stem cell transplant. Methods We selected eight patients who have been received allo-HSCT from 1999 to 2008. All patients received the combination of rapamycin and basic immunosuppressant to treat GVHD. Results One obtained complete remission,two patients improved obviously,two of them who had chronic extensive graft versus host disease improved persistently and remained disease-free survival. Five patients died. Conclusions Rapamycin can inhibit T-lymphocyte proliferation and enhance immunotolerance. It had curative effect in refractory GVHD,but it had more side effect and obviously suppressed bone marrow and often developed complications of severe infection and haemorrhagia." @default.
- W2387848892 created "2016-06-24" @default.
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- W2387848892 date "2009-01-01" @default.
- W2387848892 modified "2023-09-26" @default.
- W2387848892 title "Primary study on treatment of rapamycin in graft versus host disease after allogeneic hematopoietic stem cell transplant" @default.
- W2387848892 hasPublicationYear "2009" @default.
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