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- W2387858963 abstract "Objective:To investigate the effect of traditional Chinese medicine osteopractic total flavone(OTF)on rabbit anterior cruciate ligament transection(ACLT)model of osteoarthritis in rats.Methods:30 New Zealand white rabbits were randomly divided into five groups of six rabbits each:Sham-operated group,ACLT 4-week group,ACLT 8-week group,OTF 4-week group,OTF 8-week group.In accordance with anterior cruciate ligament transection model of knee osteoarthritis was established in rabbits.At 4 and 8 weeks the experimental animals were killed,serum levels of IL-1β and PGE2 were examined by ELISA,and NO content in synovial fluid was determined by nitrate reductase.Pieces of articular cartilage were cut,and the expression of iNOS was measured by RT-PCR.Results:The expression levels of IL-1β,PGE2,NO and iNOS in anterior cruciate ligament transection groups were significantly higher compared with sham-operated group(P0.05),and increased with modeling time(P0.05).The expressions in osteopractic total flavone groups were significantly lower than those in the ACLT groups(P0.05).Conclusion:IL-1β,PGE2,NO in the pathological process of osteoarthritis may play an important role.Chinese medicine osteopractic total flavonoids can inhibit the above-mentioned factors and down-regulate iNOS expression in articular cartilage,which can help to achieve the goal of prevention and treatment of osteoarthritis." @default.
- W2387858963 created "2016-06-24" @default.
- W2387858963 creator A5033989743 @default.
- W2387858963 date "2010-01-01" @default.
- W2387858963 modified "2023-09-23" @default.
- W2387858963 title "Experimental study on osteopractic total flavone in the treatment of knee osteoarthritis in rabbit" @default.
- W2387858963 hasPublicationYear "2010" @default.
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