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- W2387874782 abstract "Objective: To study the regulation of herbal formula gengnianchung (GNC) on neuro endocrine and immune network in postmenopausal syndrome. Methods: The clinical and experimental studies were conducted with radioligand binding assay (hydroxylapatite absorption separation), immunohistochemistry, MTT, radioimmunoassay, and Northern blot. Results: (1)In 81 women with post menopausal syndrome, the symptoms were relieved or improved obviously after GNC were taken, 92 percent of them were cured for flush. In 7 cases who did not respond to estrogen treatment, GNC produced good curative effect in 6 of them. Even though levels of serum FSH, LH decreased obviously, serum E 2 remained unchanged in the patients treated with GNC, which suggested that GNC can enhance the estrogen like effects without increase of serum E 2.(2) In old female rats fed with GNC, the level of serum E 2 did not rise, level of serum T lowered, estrogen receptor(ER) and ER mRNA expression in hypothalamus, pituitary and ovary and spleen increased. The lowered β EP in blood and hypothalamus were elevated, the increased substance P significantly decreased, serotonin in dorsal raphe nucleus increased significantly. (3)Levels of splenic ER and IL 2 activities increased significantly. Conclusion: GNC can regulate neuroendocrine and immune network in postmenopausal syndrome by raising the level of ER and not by increasing serum E 2" @default.
- W2387874782 created "2016-06-24" @default.
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- W2387874782 date "2000-01-01" @default.
- W2387874782 modified "2023-09-24" @default.
- W2387874782 title "The clinical and experimental study of herbal formula gengnianchung in treating perimenopausal syndrome: regulation of neuroendocrine and immune network" @default.
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